Official Rules of Canasta and how to play Classic Canasta. Canasta may be played with 2, 3, 4, 5 or 6 players but is best played with four persons as a. All other rules are the same as in four - player Classic Canasta. The target score is points; when one or. Here are the rules for playing the original forms of canasta. . Three-handed canasta may be played under the same rules as 4 -handed canasta, or with the rule. If you have a card you know they need, throw it. A player with only one card left in his hand may not take the discard pile if there is only one card in it. The remaining cards, from 4 up to ace, are called natural cards. Jokers and 2's are wild and can be any value except 3's A meld of 7 is a "Canasta. The play moves in a clockwise rotation, with each player picking up a card, making a meld or holding on to his or her cards, and play.de discarding, until a player goes out by getting rid of all his cards but one, and then discarding the last card, which finishes the hand. Player MAY NOT drop cards onto their opponents' melds.